Leeds Centre for Crystallization

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PhD positions

Computer modeling of normal and aberrant self-assembly in biological systems

Stefan Auer (School of Chemistry, Centre for Molecular Nanoscience (CMNS))

Understanding the fundamental laws underlying the assembly of peptides and proteins into highly organised structures is one of the scientific grand challenges for the future because of its implications for human health and nanoscience. Biomolecular self-assembly is a key element that determines the way in which biological systems function and are regulated, and its failure is associated with devastating diseases such as Alzheimer’s and Parkinson’s disease. On the other hand controlling the self-assembly of biomolecules into well ordered molecular building blocks represents the essence of modern nanotechnology and applications of peptide building blocks in bio-sensors, tissue engineering, and antibacterial agents have already been demonstrated.

The research project aims to use computational tools developed in soft matter physics to investigate the generic aspects of the nucleation and regulation of normal and aberrant self-assembly in biological systems.

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